Search results for " VALIDATION"
showing 10 items of 313 documents
Design and experimental validation of a magnetic device for stem cell culture.
2020
Cell culture of bone and tendon tissues requires mechanical stimulation of the cells in order to mimic their physiological state. In the present work, a device has been conceived and developed to generate a controlled magnetic field with a homogeneous gradient in the working space. The design requirement was to maximize the magnetic flux gradient, assuring a minimum magnetizing value in a 15 mm × 15 mm working area, which highly increases the normal operating range of this sort of devices. The objective is to use the machine for two types of biological tests: magnetic irradiation of biological samples and force generation on paramagnetic particles embedded in scaffolds for cell culture. The…
LAI, FAPAR and FCOVER ground-truth map creation from FASat-C satellite imagery and in-situ measurements in Chimbarongo, Chile, for satellite products…
2016
[EN] In remote sensing, validation exercises are essential to ensure the quality of the products originated from satellite Earth observations. To assess the measurement uncertainty derived from satellite products, several ground field data from different ecosystems must be available for use. In the same order of importance, it is necessary to define data sampling and up-scaling methodologies to allow a suitable comparison between the ground data and the pixel size of the product. This paper shows the applied methodology used in the FP7 ImagineS project (Implementing Multi-scale Agricultural Indicators Exploiting Sentinels) to validate 10-days global LAI, FAPAR and vegetation cover products …
Towards a long-term dataset of ELBARA-II measurements assisting SMOS level-3 land product and algorithm validation at the Valencia Anchor Station
2015
[EN] The Soil Moisture and Ocean Salinity (SMOS) mission was launched on 2nd November 2009 with the objective of providing global estimations of soil moisture and sea salinity. The main activity of the Valencia Anchor Station (VAS) is currently to assist in a long-term validation of SMOS land products. This study focus on a level 3 SMOS data validation with in situ measurements carried out in the period 2010-2012 over the VAS. ELBARA-II radiometer is placed in the VAS area, observing a vineyard field considered as representative of a major proportion of an area of 50×50 km, enough to cover a SMOS footprint. Brightness temperatures (TB) acquired by ELBARA-II have been compared to those obser…
Technical Note on the quality of DNA sequencing for the molecular characterisation of genetically modified plants
2018
Abstract As part of the risk assessment (RA) requirements for genetically modified (GM) plants, according to Regulation (EU) No 503/2013 and the EFSA guidance on the RA of food and feed from GM plants (EFSA GMO Panel, 2011), applicants need to perform a molecular characterisation of the DNA sequences inserted in the GM plant genome. The European Commission has mandated EFSA to develop a technical note to the applicants on, and checking of, the quality of the methodology, analysis and reporting covering complete sequencing of the insert and flanking regions, insertion site analysis of the GM event, and generational stability and integrity. This Technical Note puts together requirements and r…
Fishery-dependent and -independent data lead to consistent estimations of essential habitats
2016
AbstractSpecies mapping is an essential tool for conservation programmes as it provides clear pictures of the distribution of marine resources. However, in fishery ecology, the amount of objective scientific information is limited and data may not always be directly comparable. Information about the distribution of marine species can be derived from two main sources: fishery-independent data (scientific surveys at sea) and fishery-dependent data (collection and sampling by observers in commercial vessels). The aim of this paper is to compare whether these two different sources produce similar, complementary, or different results. We compare them in the specific context of identifying the Es…
Dynamic Response of a Rigital Displacement Motor Operating with Various Displacement Strategies
2019
Digital displacement technology has the potential of revolutionizing the performance of hydraulic piston pumps and motors. Instead of connecting each cylinder chamber to high and low pressure in conjunction with the shaft position, two electrically-controlled on/off valves are connected to each chamber. This allows for individual cylinder chamber control. Variable displacement can be achieved by using different displacement strategies, like for example the full stroke, partial stroke, or sequential partial stroke displacement strategy. Each displacement strategy has its transient and steady-state characteristics. This paper provides a detailed simulation analysis of the transient and steady…
Dry selection and wet evaluation for the rational discovery of new anthelmintics
2017
Helminths infections remain a major problem in medical and public health. In this report, atom-based 2D bilinear indices, a TOMOCOMD-CARDD (QuBiLs-MAS module) molecular descriptor family and linear discriminant analysis (LDA) were used to find models that differentiate among anthelmintic and non-anthelmintic compounds. Two classification models obtained by using non-stochastic and stochastic 2D bilinear indices, classified correctly 86.64% and 84.66%, respectively, in the training set. Equation 1(2) correctly classified 141(135) out of 165 [85.45%(81.82%)] compounds in external validation set. Another LDA models were performed in order to get the most likely mechanism of action of anthelmin…
First report on the presence of Alloxan in bleached flour by LC-MS/MS method
2017
Abstract In this work the presence of Alloxan in bread, pastry and cake bleached flour was investigate in order to verify possible risk for consumers related to the use of chemicals for flour bleaching. A selective UHPLC–MS/MS method has been developed and validated for the purpose. Alloxan is one of the possible minor side products of oxidation after chemical bleaching of wheat flours, when several chemical agents are used. One hundred and seventy-five flour samples were analyzed for Alloxan determination. The validation of the method was performed in accordance with the ISO/IEC/EN 17025 for linearity, detection limit, quantification limit, accuracy, precision and ruggedness determination.…
Determinants of the Quality of Warfarin Control after Venous Thromboembolism and Validation of the SAMe-TT2-R2 Score: An Analysis of Hokusai-VTE.
2019
Background Time in therapeutic range (TTR) measures the quality of vitamin K antagonist (VKA) anticoagulation. In patients with atrial fibrillation, the dichotomized SAMe-TT2-R2 score (≥2 vs. < 2 points) can predict if adequate TTR is unlikely to be achieved. Aims We validated the SAMe-TT2-R2 score in patients with venous thromboembolism (VTE) randomized to the warfarin arm of the Hokusai-VTE trial. Patients and Methods A total of 3,874 patients were included in the primary analysis (day 31–180 from randomization). The efficacy and safety outcomes were symptomatic recurrent VTE and major or clinically relevant non-major bleeding. Results The rates of recurrent VTE and bleeding events we…
A multicentric study to evaluate the use of relative retention times in targeted proteomics.
2016
Despite the maturity reached by targeted proteomic strategies, reliable and standardized protocols are urgently needed to enhance reproducibility among different laboratories and analytical platforms, facilitating a more widespread use in biomedical research. To achieve this goal, the use of dimensionless relative retention times (iRT), defined on the basis of peptide standard retention times (RT), has lately emerged as a powerful tool. The robustness, reproducibility and utility of this strategy were examined for the first time in a multicentric setting, involving 28 laboratories that included 24 of the Spanish network of proteomics laboratories (ProteoRed-ISCIII). According to the results…